2. Signaling Pathways
  3. PROTAC
  4. Ligands for Target Protein for PROTAC

Ligands for Target Protein for PROTAC

Target Protein-binding Moiety

Ligands for Target Protein for PROTAC

Related Products

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The PROTAC molecule consists of a target protein ligand and an E3 ubiquitin ligase ligand, with a linker binds them together. The ligand for target protein will lead to attachment of a PROTAC to the proteins of interest for ubiquitin and subsequent degradation.

Target proteins are usually proteins whose overexpression or accumulation may play important roles in the progress of diseases. Numbers of PROTACs have been developed to degrade kinases (such as MEK, KRAS, CDK and Bcr/Abl), transcription factors (such as p53, STAT, RAR, ER and AR), epigenetic tools (such as HDAC and BET bromodomain) and E3 ligase themselves (such as MDM2).

Ligands for Target Protein for PROTAC Related Products (520):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-176442
    SARS-CoV-2 Mpro ligand 1
    SARS-CoV-2 Mpro ligand 1 (Compound S15) is a PROTAC target protein ligand. SARS-CoV-2 Mpro ligand 1 can be used to synthesize BP-198 (HY-176440).
    SARS-CoV-2 Mpro ligand 1
  • HY-168965
    BTK ligand 15 2668225-98-5
    BTK ligand 15 is the target protein ligand of PROTAC BTK Degrader-13 (HY-168963). PROTAC BTK Degrader-13 can selectively degrade BTK.
    BTK ligand 15
  • HY-W539427
    BRM/BRG1 ligand 1 1893977-70-2
    BRM/BRG1 ligand 1 is a BRM/BRG1 ligand, and can be used for synthesis of PROTAC BRM/BRG1 degrader-1 (HY-168242).
    BRM/BRG1 ligand 1
  • HY-W1122565
    KAT2A/B ligand 1 2254066-18-5
    KAT2A/B ligand 1 (compound 32a) is a KAT2A/B ligand. KAT2A/B ligand 1 can be used as a target protein ligand for the synthesis of AUR1545 (HY-173158).
    KAT2A/B ligand 1
  • HY-161931
    Demethyl-RSL3-boc 2375354-07-5
    Demethyl-RSL3-boc is a ligand for target protein for pROTAC.
    Demethyl-RSL3-boc
  • HY-161807
    DENV ligand 1 1628758-48-4
    DENV ligand 1 is a ligand for DENV E protein. DENV ligand 1 can be utilized for synthesis of PROTAC Degrader ZXH-8-004 (HY-161806).
    DENV ligand 1
  • HY-107442R
    PROTAC BRD4-binding moiety 1 (Standard) 2101200-10-4
    PROTAC BRD4-binding moiety 1 (Standard) is the analytical standard of PROTAC BRD4-binding moiety 1 (HY-107442). This product is intended for research and analytical applications. PROTAC BRD4-binding moiety 1 is a ligand for BRD4. PROTAC BRD4-binding moiety 1 binds to cereblon ligand via a linker to form PROTAC to degrade BRD4 (HY-133136). PROTAC BRD4-binding moiety 1 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    PROTAC BRD4-binding moiety 1 (Standard)
  • HY-161711
    CBP/p300 ligand 5
    CBP/p300 ligand 5 is the target protein ligand of XYD129 (HY-161710). CBP/p300 ligand 5 can be used to study the acute myelogenous leukemia.
    CBP/p300 ligand 5
  • HY-159472
    SMARCA2/4-ligand-1 2411651-36-8
    2-(6-Amino-5-(1-(piperidin-4-ylmethyl)-1H-pyrazol-4-yl)pyridazin-3-yl)phenol is a Ligand for target protein for pROTAC.
    SMARCA2/4-ligand-1
  • HY-176129
    AR ligand 41
    AR ligand 41 is a PROTAC target protein ligand (Ligands for Target Protein for PROTACs). AR ligand 41 can be used for the synthesis of BWA-6047 (HY-176128).
    AR ligand 41
  • HY-168671
    pan-KRAS ligand 1 2886012-31-1
    pan-KRAS ligand 1 is a Ligand for Target Protein for PROTAC. pan-KRAS ligand 1 can be used for synthesis PROTAC pan-KRAS degrader 4 (HY-168669).
    pan-KRAS ligand 1
  • HY-183063
    SMARCA2/4-ligand-7 2892523-96-3
    SMARCA2/4-ligand-7 is a SMARCA2/4 ligand, which can be used for the synthesis of PROTACs, such as PROTAC SMARCA2/4 degrader-41 (HY-153425).
    SMARCA2/4-ligand-7
  • HY-168305
    EGFR ligand-11 2550394-08-4
    EGFR ligand-11 is a target protein ligand for EGFR and can be used to synthesize PROTAC MS154 (HY-141640).
    EGFR ligand-11
  • HY-178094
    BRD4 ligand 13 1101702-81-1
    BRD4 ligand 13 is a BRD4 ligand that can be used for the synthesis of PROTACs, such as Cath-L-dBET1 (HY-173257). BRD4 ligand 13 is a target protein ligand-conjugate that can be used for the synthesis of PROTACs, such as SJH1-51B (HY-162240).
    BRD4 ligand 13
  • HY-118271
    GNF-8625 1196546-33-4
    GNF-8625 is a broad-spectrum TRK inhibitor that can combine with Thalidomide to form a PROTAC degrader. The IC50 of GNF-8625 for inhibiting TRKA, TRKB, and TRKC are 0.8 nM, 22 nM, and 5.4 nM, respectively.
    GNF-8625
  • HY-185575
    ATM ligand-1 3056059-49-2
    ATM ligand-1 is an ATM ligand that can be used for the synthesis of PROTACs, such as PROTAC ATM degrader-1 (HY-158345).
    ATM ligand-1
  • HY-172369
    CARM1/IKZF3 ligand 1
    CARM1/IKZF3 ligand 1 is the inhibitor for CARM1 that can be used as the target protein ligand for synthesis of PROTAC CARM1/IKZF3 degrader-1 (HY-172368).
    CARM1/IKZF3 ligand 1
  • HY-170599
    H117 99.27%
    H117 is a PROTAC target protein ligand that can be used to synthesize PROTAC HP211206 (HY-170598). H117 has competitive binding and inhibition ability on SARS-CoV-2 main protease (Mpro) with an IC50 of 151.3 nM.
    H117
  • HY-182352
    RXRγ antagonist-1
    RXRγ antagonist-1 (HX531 analogue) is an RXRγ antagonist and can be used as a target protein ligand for the synthesis of PROTAC WCF-598 (HY-182331).
    RXRγ antagonist-1
  • HY-168252
    BRM/BRG1 ligand 3 2933126-51-1
    BRM/BRG1 ligand 3 is a target protein ligand that can be used to synthesize PROTAC BRM/BRG1 degrader-3 (HY-168251).
    BRM/BRG1 ligand 3